Cellular Mechanism of the QT Prolongation Induced by Sulpiride
نویسندگان
چکیده
منابع مشابه
Drug induced QT prolongation.
The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...
متن کاملDrug-Induced Prolongation of the QT Interval
N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...
متن کاملDrug-induced prolongation of the QT interval.
N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...
متن کاملCocaine induced prolongation of the QT interval.
P rolongation of the QT interval is a serious electrocardiogram finding because of its association with torsades de pointes and sudden cardiac death. Both congenital and acquired factors can lead to abnormal lengthening of the QT interval. Six types of congenital long QT syndrome (LQT1– LQT6) have been described, each involving mutations in genes encoding potassium or sodium transmembrane chann...
متن کاملProlongation of the QT interval by ketanserin.
In hypertensive patients single doses of ketanserin 40 mg prolonged the corrected QT interval (QTc) for at least 8 hours, with a maximal increase of 35 ms (P less than 0.001, n = 6) after 2 hours. During chronic dosing (20 and 40 mg b.d.) the QTc was further prolonged, by 46 and 45 ms respectively. QTc prolongation after treatment with a mean dose of 73 mg/day for 7 weeks (n = 26) was significa...
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ژورنال
عنوان ژورنال: International Journal of Toxicology
سال: 2009
ISSN: 1091-5818,1092-874X
DOI: 10.1177/1091581809337261